We’re beyond excited to introduce PEDGA’s very first podcast episode! 🎉 At Pediatric Gastroenterology Associates (PEDGA), we’re always looking for new ways to bring valuable information to parents, and our podcast is the perfect way to share expert insights on pediatric digestive health.
For our debut episode, we’re kicking things off with none other than Dr. Jesse Reeves-Garcia, a highly respected pediatric gastroenterologist with years of experience in diagnosing and treating digestive conditions in children.
Episode 1: Understanding Polyps in Children
Polyps aren’t just something adults deal with—children can develop them too! In this episode, Dr. Jesse Reeves-Garcia breaks down:
- What are polyps, and why do they form in children?
- Are they dangerous, and when should parents be concerned?
- How are polyps diagnosed and treated?
- Can polyps be prevented, and what’s the long-term outlook
If you’ve ever had questions about polyps, or if your child has been diagnosed with one, this episode is a must-listen for understanding what to expect and how to manage this condition.
Why You Should Tune In
At PEDGA, we believe education empowers parents to make the best decisions for their child’s health. Our podcast is designed to provide trusted, expert-backed information in an engaging and easy-to-digest format.
With each episode, we will:
- Break down complex medical topics in simple terms.
- Address common concerns that parents have about pediatric GI health.
- Share expert advice from our team of board-certified pediatric gastroenterologists.
- Offer real-life solutions to help children thrive.
By tuning in, you’ll gain practical knowledge that can help you recognize symptoms early, make informed health choices, and better understand your child’s digestive health.
Where to Listen 🎧
We understand that parents are busy, so we’ve made it easy for you to tune in! Listen to PEDGA’s first podcast episode on:
Don’t forget to subscribe so you never miss an episode! Each month, we’ll be bringing you expert insights on common pediatric GI issues, straight from our team of dedicated doctors.
We’re Here for You
If your child is experiencing digestive issues, abdominal pain, or other GI concerns, our expert team at PEDGA is here to help. We offer comprehensive evaluations, personalized treatments, and compassionate care to ensure your child’s well-being.
📞 Schedule an appointment today: 786-888-2480
📍 Visit us in Miami: 10045 South Dixie Highway, Miami, FL 33156
Your child’s health is our priority—wherever they need us. 💙
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Testosterone was first discovered in 1935, and in 1937 it was first used clinically3.
The discovery of the anabolic properties of AAS resulted in AAS use propagating into elite sports activities in the 1950s4.
It was not till the late Nineteen Eighties that use gained
ground amongst gym members in the basic inhabitants and is today primarily
used to improve body image and construct muscle tissue extra easily5,
6,7. Latest estimates suggest that about 2–3% of the population have used AAS at some point5,
6, however higher prevalence is seen amongst men6 and subpopulations
similar to leisure weightlifters, bodybuilders, inmates8
and substance use patients9. Anabolic androgenic steroids (AAS) comprise testosterone and its synthetic derivatives.
It is far more androgenic than Testosterone, and sufficient quantities of it in androgen dependent tissues is critical throughout puberty to ensure full maturation is achieved.
There is also hypothesis round whether or not certain Boldenone metabolites act as aromatase inhibitors and attenuate the estrogenic exercise of the father or mother hormone.
Boldenone’s degree of estrogenicity is much
less clear as there is no strong data out there that
gives details on its interaction with aromatase in humans.
At the base of the article every reference might be linked to a peer-reviewed research or
paper.
Just like testicular testosterone production,
spermatogenesis is ruled by the HPGA. The concerted action of LH and FSH on the testes stimulates spermatogenesis, and suppression of those hormones inhibits it.
FSH acts instantly on spermatogenesis by activating FSH receptors on Sertoli cells,
whereas LH works indirectly via stimulating testosterone manufacturing
by activating LHCGRs on Leydig cells, which in turn prompts ARs on Sertoli cells (179).
Despite testosterone being the first mediator of LH’s effect
on spermatogenesis, exogenous administration of testosterone cannot assist spermatogenesis.
Intratesticular testosterone (ITT) levels are about 50
to one hundred instances greater than in circulation (180) and exogenous administration severely
suppresses this to ranges that are unable to support spermatogenesis (181).
Consequently, an argument could be made to perceive these AAS-induced cardiac adjustments as threat modifiers when estimating CVD danger using algorithms corresponding to SCORE2 or PCE, and will assist in ‘grey zone’ threat estimation conditions.
The premise of hormonal male contraception hinges on the adverse suggestions exerted by intercourse hormones on LH and FSH secretion. Curiously, even a dosage
that is roughly twice that of TRT (200 mg testosterone enanthate weekly)
only partially suppresses LH (-66.7%) and FSH (-62.5%) and,
indeed, results in azoospermia in solely about
two out of three men (182).
Information regarding miRNAs in human diseases associated to AAS use/abuse could
ultimately result in determine serum or tissue biomarkers with
anti-doping potential. In this regard, the need for careful
validation of diagnostic miRNA candidates in well-annotated toxicological research is necessary.
The fast progress in anti-doping technologies utilizing miRNA primarily based methods for the discovery of
drug-abuse, similar to AAS use/abuse, might optimize new approaches primarily based on existing and emerging data.
In the absence of scientific context, interpretation of blood abnormalities can result in inappropriate or unwarranted referrals to secondary care, stretching an already burdened healthcare system.
Furthermore, these patients could then be subject to pointless investigations, for
example, an intensive liver or pituitary display.
Liver biopsy sometimes exhibits a bland cholestasis with minimal irritation and hepatocellular necrosis.
Bile duct damage is typically absent or delicate and vanishing bile duct syndrome rarely ensues.
The frequency of acute cholestasis from androgenic steroids just isn’t
well-known, however it is likely somewhat dose associated and should happen in ~1% of patients treated with methyltestosterone, danazol, stanozolol or oxymetholone.
In our expertise, a lot of AAS users wouldn’t have clear objectives for his or her use,
aside from being ‘as massive as possible’.
As outlined beforehand, there is a lack of expertise about opposed
health results of anabolic steroid abuse, especially regarding the long-term effects.
There is uncertainty about the precise contents of the abused products and there’s massive variability
in dose, length and kind of abused substances.
Almost all participants highlighted the importance of getting
blood checks to observe their health whilst utilizing anabolic steroids.
Dromostanolone is an artificial anabolic steroid that possesses anti-estrogenic properties and is approximately five occasions more potent than methyltestosterone.
Dromostanolone works by growing the retention of nitrogen, phosphorus, and potassium,
which leads to elevated protein anabolism and
a decrease within the catabolism of amino acids.
This results in a rise within the density and hardness of
muscles, which can be beneficial for bodybuilders trying to enhance their
bodily look. Because of their anabolic impact, the
drugs are sometimes abused by athletes or
individuals wanting to enhance their physical appearance.
Expression of Pax7 following DHT administration in C2C12 myoblasts was low
two days post-administration but increased to peak values 4 days post-administration (6).
Since extreme AAS-induced violence or criminality is unusual, many clinicians have
by no means immediately encountered this phenomenon, and subsequently they may misunderstand the nature of these results.
This misunderstanding is partially perpetuated by the frequent but non-scientific time period, “‘roid rage,” which might seem to suggest that AAS customers display abrupt outbursts of mood or sudden acts of violence.
ND administration had a major effect on TNFα mRNA abundance in five-month male Fisher 344xF1 Brown Norway rat
muscle solely however did not attenuate overload-induced TNFα
induction (36). ND administration resulted in no important modification to MSTN, mTOR, or
PERK expression in normal adult mice, with no impact on MSTN occurring
after denervation in male Wistar rats (3, 33, 43). ND had no effect on IGF1 mRNA expression with
or with out exercise-induced overload in four-month-old male Fisher 344x F1 Brown Norway rats (25).
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Such androgenicity is damaging to hair follicles due to elevated levels of dihydrotestosterone (DHT), causing receding and thinning on the scalp.
Trenbolone is extremely androgenic, which
can cause excess sebum production, leading to oily pores and skin and pimples vulgaris.
Nonetheless, the two hottest SERMs, Nolvadex and Clomid,
should not be taken with trenbolone, as they will increase progesterone levels, worsening tren-induced
gynecomastia in our expertise.
When you cease steroid misuse or abuse, it takes your physique weeks to months to get again to creating its own testosterone.
Steroid abuse usually involves massive doses of illegally sourced medicine, that provide a vastly higher level of hormones than required for reliable testosterone replacement therapy.
Some customers could turn into aggressive or combative, consider
issues that aren’t true (delusions), or have excessive feelings of distrust or
worry (paranoia). And individuals who use steroids additionally seem like at higher threat PCT Essentials for Bodybuilding Cycles using other medicine, corresponding
to alcohol or cocaine, often to counteract some of the negative
results of steroids. Corticosteroids, corresponding to cortisone, are drugs that docs prescribe to help control irritation.
For instance, it can result in water retention, elevated blood stress, and tender nipples in males.
Okay, the wonderful news is that this steroid isn’t practically as Estrogenic as a few
of the different steroids usually used by bodybuilders.
This lets you practice heavy through the off-season, and the
heavier you can prepare the more muscle mass you will doubtless have
the ability to build. As we checked out beforehand, this steroid may be stacked with different compounds and can be utilized for
bulking or cutting cycles.
I had completed a stage race in Southern Spain, like a week-long stage race, and I was
just like a starfish on my bed, collapsed. He was sporting this fly fishing vest and he
reached into one of many pockets and he pulled out this little purple,
egg-shaped capsule. It’s not doping, it’s on your health.” Yeah, it had testosterone in it. And that was the second, he handed me this capsule, that was the moment.
This agent differs from nandrolone by the addition of a 17-alpha ethyl group to reduce back first-pass metabolism, as well as by the deletion of the 3-keto group. This steroid was first commercially manufactured in 1960 by Ciba underneath the model name Dianabol and rapidly grew to become probably the most used and abused steroid worldwide, remaining so thus far. It jokingly came to be known as “the breakfast of champions” in sports circles. Methyltestosterone is metabolized by aromatase to the potent estrogen 17-alpha methyl estradiol and can additionally be lowered by 5AR to 17-alpha methyl dihydrotestosterone. The primary medical use of beta-blockers is to regulate hypertension, cardiac arrhythmias, angina pectoris (severe chest pain), migraine, and nervous or anxiety-related situations. Note that individual progress factors are still prohibited when given individually as purified substances as described in S.2.5. In common, it’s like, people have type of come and advised their reality or not informed the reality and kind of moved on.
Trenbolone is arguably probably the most highly effective steroid out there to bodybuilders, causing fast adjustments in body composition that happen inside the first week of use. Androgen receptors are present in fats cells, and thus, when stimulated, lipolysis will increase (4). This is because of its distinctive muscle-building and strength-enhancing effects (similar to Anadrol), but with slightly fewer side effects. Anadrol will cause hefty weight acquire, approximately 30 lbs from a cycle, due to it being a wet steroid in addition to anabolic. Anadrol is also some of the highly effective compounds for enhancing strength, making it very popular among strongmen and powerlifters, in our expertise. Nonetheless, there isn’t any proof that these methods cut back side effects and harm from taking steroids. It’s important to speak with your doctor about any well being issues you might have earlier than you start utilizing steroids.
When injected within the correct dosages, we find testosterone to be one of the most secure steroids out there. Testosterone is an FDA-approved injectable steroid used to treat tens of millions of males all over the world who are deficient in natural testosterone. Trenbolone additionally has strong fat-burning properties (39); thus, we now have seen it effectively utilized in chopping cycles. Thus, there’s not much profit in including creatine to your Dianabol cycle. However, there are considerable drawbacks, as it can amplify some of the unwanted effects experienced with Dianabol. Equally, for optimum results, ensure frequent doses are taken all through the day (every 2–4 hours). We have seen users abstain from lifting weights and nonetheless see noticeable improvements in physique composition (being sedentary) from Dianabol use.
Nonetheless, together with its advantages come important considerations regarding its potential side effects and correct usage. Hormonal SuppressionOne main mechanism by which steroids affect sexual function is through the suppression of pure testosterone manufacturing. When artificial testosterone is launched, your physique reduces its own manufacturing, leading to hormonal imbalances. This imbalance may find yourself in decreased libido and erectile dysfunction, severely affecting sexual well being. Dianabol raises blood strain like all anabolic steroids, albeit to a more notable diploma, due to its huge impact on water retention (making blood volume more and more viscous). Testosterone can be administered parenterally, however it has more irregular prolonged absorption time and larger exercise in muscle in enanthate, undecanoate, or cypionate ester kind.
While it’s essential to know these, we shouldn’t simply assume that we will use just
any method for steroids. As you will note, one technique
in particular ought to by no means be used and comes with a seriously high danger
of dying. Even if you’ve injected a number of times already,
you’ll need to be sure you’re doing it
right each time to get the most effective outcomes and keep
your health. Beneath, you’ll discover the most comprehensive information to injecting steroids,
containing every little thing you have to know to get it
right each time. Each cycle is proscribed to 4-6 weeks
and consists of just one steroid compound per cycle.
Every woman may have a different tolerance relating to how
much adverse impact she is keen to cope with.
As we age our pure testosterone ranges start to rapidly decline;
especially as we attain the age of thirty.
If you’ve observed a lack of muscle mass, excess
body-fat even with the identical diet and train program, lethargy or decreased libido,
you could qualify for a prescription. In some cases these
youthful than the age of thirty will qualify
but thirty is commonly the age many physicians use as the place to begin. For the utilization and dosage of
anabolic steroids, please check with the professional
guidance offered by the original pharmaceutical company.
Approximately 3 to 4 million individuals within the United States
use anabolic steroids for nonmedical functions.
Urs Labs is a trusted provider of steroids which are tested for purity and effectiveness.
They present a range of merchandise designed for different health targets, whether or not
you’re seeking to construct mass, minimize fats, or boost endurance.
Urs Labs additionally offers secure and discreet delivery to protect consumer privacy,
making it a preferred choice for steroid patrons worldwide.
Roid Store supplies a big selection of anabolic steroids and
muscle-building dietary supplements, catering to both newbies and superior users.
Their inventory is sourced from respected producers, and the positioning provides
detailed data on correct usage and cycles for each product.
Roid Shop additionally ensures discreet packaging and a easy buying course of, making it
a dependable selection for lots of.
Prioritizing compliance with rules is essential
for a lawful and safe acquisition course
of. Some athletes could appear to get an edge from performance-enhancing
medication. Some drugmakers and workout magazines claim that andro products
assist athletes train harder and recover sooner. You ought to have common appointments with your healthcare supplier
when taking an anabolic steroid to assess how nicely it’s working.
People who use anabolic steroids on a routine basis can have withdrawal signs once they cease
taking them. Symptoms include having despair, being extremely tired, and having
no want to eat. Testosterone plays a vital role not solely in constructing muscle mass
but additionally in burning calories successfully. This naturally occurring compound is integral to enhancing bodily exercise ranges, bettering temper, sex
drive, cognitive perform, and general high quality of life.
Moreover, select steroids have been proven to assist in reducing water weight, resulting in a extra
toned and tightened physique. Efficient steroids for fats burning include T3, Cardarine,
and Clenbutrol. However, it’s important to source steroids
from reputable distributors when contemplating their
use for weight loss purposes.
Testosterone is the primary endogenous hormone belonging to
this class. It is broadly used therapeutically, in varied esterified forms, as replacement remedy in male hypogonadism.
Testosterone, and a select few different AAS such as nandrolone
and oxandrolone, may also be prescribed for different medical situations (e.g.,
osteoporosis or aplastic anemia). In Addition To this legitimate medical use, AAS are broadly used – or quite,
abused – for his or her muscle-building and
strength-increasing properties in dosages far exceeding those used therapeutically.
For brevity, within the the rest of this evaluate we make use of the term ‘AAS use’
to check with the nonmedical high-dose abuse of AAS.
Navigating the online market for steroids is often a challenge, with countless websites offering products that declare to spice up efficiency
and muscle development.
Browse our curated list of one of the best and most trusted steroid sources online.
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Whether Or Not you’re planning a full anabolic cycle or need dependable post-cycle remedy (PCT), these verified suppliers are
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Consulting a healthcare supplier is important earlier than considering steroid use.
It is necessary to be careful and familiar when you purchase steroids in bulk.
First of all, age is necessary; steroids are only used by individuals over the age of 21 to keep away from
inhibiting natural growth. It is the time for your
physique to generate its construction, and
hormones – in abstract, it’s your potential for the future.
Anabolic-androgenic steroids (AAS) are synthetic (manufactured) versions of the male sex hormone testosterone.
This is a variety of the most important information about oral and injectable steroids in bodybuilding that can be very beneficial to any athlete and/or bodybuilder.
Take this quick quiz — we’ll recommend fundamental cycle tailored
to your gender, age, and health objectives (muscle
gain, fat loss, endurance, and so forth.).
That similar examine has also decided that the typical anabolic steroid user held a much larger employment fee in addition to an overall larger family
earnings than that of the remainder of the overall inhabitants.
There are a number of choices you may have available for obtaining
a prescription for anabolic steroids. The process
is straightforward; blood is drawn, hormonal levels are checked, similar to your
free testosterone.
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